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Amidites for the study of epigenetics

Epigenetics is an exciting field of modern (molecular) biology, as it has been demonstrated that the genetic information is not only limited to the base sequence (genetic information). Base modifications, especially 5-methyl deoxycytidine (5-mdC) play a crucial role in the silencing of genes. More recently, it has been discovered that oxidized variants of 5-mdC could have a biological function in the reactivation process of silenced genes.
A major hypothesis has proposed eradication of 5-mdC through stepwise oxidation by Tet enzymes and decarboxylation to yield the "active" dC.
5-Hydroxymethyl cytidine (5-hmdC) is the first oxidized variant of 5-mdC and was found to be semi-permenant nucleoside in the cortex of vertebrates. In order to study distinct sequences containing 5-hmdC modifications it is necessary to synthesize oligonucleotides by solid-phase synthesis. Our 5-hydroxymethyl cytidine CEP is the ideal building block to generate 5-hmdC modified oligonucleotides.

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