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Cell Imaging Reagents

The visualisation of cellular structure and function, together with cellular metabolism and metabolites is vital for generating new knowledge for cell biology or to define mechanisms of diseases. Together with our partner ReZolve Scientific we are glad to provide you reagents aimed to helping you to answer these important scientific questions.
ReZolve cell imaging reagents offer the ability to capture important cellular processes such as energy storage, cell signaling, metabolic processes and membrane dynamics in real time. These reagents are capable of dissecting both structure and function at the sub-cellular level, have high clarity and do not fade. There is also minimal to no toxicity, so they are suitable for live cell imaging.

Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex, has achieved Scientific Reports Top 100 articles for cell and molecular biology papers in 2018.
The publication by Alexandra Sorvina is on IraZolve-Mito.
The report can be accessed via ReZolve Scientific website, or here: https://www.nature.com/articles/s41598-018-24672-w


Communications
 
The ReZolve March newsletter focused on the difference between our products (ie. ReZolve-L1 vs IraZolve-L1, etc).  Please follow this link:
https://mailchi.mp/rezolvescientific/trying-to-decide-on-a-fluorophore
 
The April Newsletter - see link: https://mailchi.mp/rezolvescientific/irazolve-mito-publication-in-top-100-scientific-reports
This month we are highlighting the publication in Scientific Reports, and searching for IraZolve-Mito images and recommendations - to showcase the product, researchers and the diverse research areas.
 
 
Presentation
 
ReZolve director, Dr Sally Plush of UniSA, has recently held a presentation on ReZolve products.  The presentation was heavily based on a publication in FEBS Press. (See publications on our website or this link: https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.12365)
 
Key points:
 
ReZolve products are favourable for research, as they are photostable with fast cellular uptake. The inclusion of a ligand reduces the toxicity by moving the Iridium or Rhenium based complex into neutral state.
 
ReZolve-ER is passively absorbed, it freely transits across the cell membrane, and can be detected at low frequency seconds after applying.  The fluorophore does not interfere with the functioning of the organelle, and can be washed from cells if required.
 
ReZolve‐ER™ does not photobleach when exposed to high laser power. (A–C) Confocal micrographs of PNT2 cells incubated with ReZolve‐ER™ for 0 min (A), 15 min (B) and 29 min (C). Overlay shows the regions of interest from which emissions intensity was measured. (D) Scatter plot showing average emission intensity (au) of ReZolve‐ER™‐stained cells from regions of interest indicated. Images collect with 403 nm excitation set to laser power 10, a scan rate of 0.22 s (give a total of 448 scans over 29 min) and a pixel dwell time of 0.22 ms.

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