New baseclick Article published in Angewandte Chemie (Wiley)
baseclick GmbH successfully showed the formation of highly complex and stable DNA-Catenanes containing 24 topologically interlocked DNA rings in a one-pot fashion. The newly formed DNA-nanostructure resembles – at nano meter size - the chainmail architecture of coats typically used by the medieval knights. Accordingly, such high-member rings DNA-catenane has been called “Chain Armor DNA”. These unprecedented stable versions of self-assembled DNA-nanostructures have a broad applications range from nanoelectronics and nanooptics to nanomedicine and diagnostics. Moreover stable DNA containers can be used for efficient and specific drug delivery. A sophisticated arrangement of 24 functionalized oligonucleotides (so-called "click tiles") in a nanotube structure allows simultaneous ring closure of all oligonucleotides via click chemistry, the core technology of baseclick GmbH. This development could be the basis for a successful application of these systems in vitro and in vivo. The article describes fundamental research aiming for using DNA in the field of "drug delivery". The project was supported by an EU grant “training network EScoDNA (FP7-ITN)”. "The results showed that the technology developed by baseclick might have great potential in nanotechnology. These catenene constructs not only allow stabilization of the overall structure, but also bridge the gap between high potential nanostructures and biomedical applications,” so Dr. Antonio Manetto, CSO of baseclick GmbH.
This article can be accessed using the following reference in the journal Angewandte Chemie: V. Cassinelli, B. Oberleitner, J. Sobotta, P. Nickels, G. Grossi, S. Kempter, T. Frischmuth, T. Liedl and A. Manetto, One-Step Formation of “Chain-Armor”-Stabilized DNA Nanostructures, Angew. Chem. Int. Ed. 2015, 54, 7795-7798; Angew, Chem. 2015, 127, 7905-7909.