mRNA modification for stabilization and reduced immunogenicity
The problem:
mRNA exhibits outside and inside the body instability and immunogenicity
- RNA is highly sensitive to nucleases (RNase) outside and inside to body
- RNA is highly sensitive to pH changes and oxygen
- Inside cells decayed mRNA leads to innate immune response
Our solution:
Stabilization and reduced immunogenicity of mRNA via incorporation of modified nucleotides
- baseclick developed new modified nucleotides which are incorporated during mRNA synthesis from 5’- to 3’-mRNA ends
- baseclick is offering products and services for modified mRNA synthesis
The outcome:
Modified mRNA is protected against enzymatic and chemical attack
- Incorporation of modified CAP analogs, EUTP and modified Adenosine nucleotides
- Chemical conjugation of incorporated modified nucleotides
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