Our Mission

Who we are

• We have been pioneers in Click Chemistry since the early development of the concept, which is honored with the Nobel Prize in Chemistry in 2022. At baseclick, we are constantly innovating to unlock its vast potential through new applications.
• We offer the most versatile and innovative range of Click Chemistry products, from chemical reagents and advanced kits for diverse biological applications and drug development to custom oligonucleotide and mRNA production services.
• We are committed to supporting our customers in all aspects of Click Chemistry, from early-stage consulting to hands-on support throughout their projects.

ClickSeq: A Chemically Driven Alternative for RNA and DNA Library Preparation

Discover the molecular foundations and key advantages of ClickSeq, a fragmentation and ligation free method for preparing NGS libraries. This video explains how azide-modified nucleotides and copper-catalyzed click chemistry enable high-fidelity sequencing with minimal artifacts, making it ideal for RNA viruses, transcriptomic studies, and complex genome analyses.

Ligand mediated cell targeting

The problem:

The cell membrane is a natural barrier preventing molecules from entering the cell

• RNA is water soluble but not lipophilic!
• RNA does not enter cells passively!

Our solution:

Ligand – receptor mediated cellular targeting and cellular uptake

• baseclick offer products and services for bioconjugation of RNA via linker with ligands such as sugars, amino acids etc.

The outcome:

Ligand modified oligos therapeutics result in better medication

• Ligand – receptor mediated drug delivery leads to improved disease medication
• Development of sugars ligands are currently the most favorable ligand – receptor oligo delivery strategy

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Superior Prep Kits for NGS

The problem:

Reliable sample preparation procedure for in depth sequence analysis

• Today sample preparation needs high input of DNA/RNA for NGS analysis
• Today sample preparation comprises several steps leading to long procedure and loss of material

Our solution:

Utilizing Click Chemistry in sample preparation

• baseclick developed new ClickSeq Library prep kits
• baseclick is offering preparation kits for RNA and DNA NGS analysis

The outcome:

Less steps, less time and less sample input

• Reduction to only 3 steps in the preparation
• Procedure only 2h
• No fragmentation step

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mRNA modification for stabilization and reduced immunogenicity

The problem:

mRNA exhibits outside and inside the body instability and immunogenicity

• RNA is highly sensitive to nucleases (RNase) outside and inside to body
• RNA is highly sensitive to pH changes and oxygen
• Inside cells decayed mRNA leads to innate immune response

Our solution:

Stabilization and reduced immunogenicity of mRNA via incorporation of modified nucleotides

• baseclick developed new modified nucleotides which are incorporated during mRNA synthesis from 5’- to 3’-mRNA ends
• baseclick is offering products and services for modified mRNA synthesis

The outcome:

Modified mRNA is protected against enzymatic and chemical attack

• Incorporation of modified CAP analogs, EUTP and modified Adenosine nucleotides
• Chemical conjugation of incorporated modified nucleotides

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High Yield mRNA synthesis

The problem:

Production of high quality mRNA for acceptable price

• Available in vitro transcription (IVT) kit do not deliver satisfying high quality mRNA for acceptable low price

Our solution:

Special T7 RNA Polymerase-Pyrophosphatase-Synthesis buffer mixture

• baseclick developed a new IVT mRNA synthesis procedure
• baseclick is offering products and services for mRNA synthesis

The outcome:

High yield high quality mRNA

• Higher yield per DNA-Template
• High quality, even up to 10kb mRNA

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