Oligonucleotide Labeling Kits
Modification of oligio nucleotides with click chemistry provides highest conjugation efficiency. The new baseclick "Oligonucleotide kits" are designed to make conventional olgonucleotide labeling reactions more user friendly with advanced technology based on click reactions - the so-called copper(I)-catalyzed azide-alkyne cycloaddition CuAAC.
The "1st Generation Oligo Kits" are based on the wide spreaded Cu(I) / TBTA catalyzed click reaction. The kit includes the azide of choice as well.
The "2nd Generation Oligo Kits" are based on a new solid heterogeneous catalyst. This air-stable, insolube Cu(I) source provided in a ready to use vial (Reactor) along with an activator allows efficient click reactions in both aqueous and organic solvents. Both catalyst and activator result in a much easier ad faster handing including only three steps:
More than 100 azides are compatible with both Oligonucleotide kit generations.