Logo BaseClick

Innovative solutions for Life Sciences: Click Chemistry for sensitive and modular labeling of nucleic acids.
 
In 2008 baseclick GmbH with its head office in Neuried, Germany was founded with the shareholders of
BASF Venture Capital GmbH, Ludwigshafen and Prof. Thomas Carell, LMU, Munich.


 
The core of the baseclick technology is the "click reaction", a copper catalyzed cycloaddition allowing virtually unlimited functionalization of both small synthetic oligonucleotides and large gene fragments with unprecedented efficiency. Characteristic therefore are the broad application possibilities, high yields and easy & quick reaction conditions using readily available and inexpensive reagents. baseclick holds granted worldwide patents for this use.
 
„The Scripps Research Institute“ patented the „click chemistry“ of the inventor B. Sharpless, Nobel laureate 2001. Beside it’s own patents baseclick holds an exclusive worldwide license for the use of this technology in the field of nucleic acids and offers this technology in research, diagnostics and, increasingly, the pharmaceutical development at by modification of RNA molecules.

Current areas of application are, among others:
 
- The detection, control and analysis of cell proliferation in vitro and in vivo;
- The labeling of DNA and RNA for the preparation of e.g. FISH probes;
- The labeling of nucleic acids and other biochemical molecules
.



Baseclick has been awarded two research grants from the European Union:

The European School of DNA Nanotechnology (EScoDNA):
EScoDNA is an Initial Training Network (ITN) under the European Commission’s Marie Curie Actions research within the 7th framework program
. All of the highly interconnected research projects ultimately aim at the common goal: to exploit DNA for the development of new functional tools for key applications sectors: life sciences and medicine.
The School is a joint initiative by leading scientists from the Universities:

  • Aarhus University, Aarhus, Denmark
  • Ludwig-Maximilians-University, Munich, Germany
  • The Technical University of Munich, Munich Germany
  • Karolinska Institutet, Stockholm, Sweden
  • University of Oxford, Oxford, United Kingdom

and the companies:

  • Vipergen ApS, Copenhagen, Denmark
  • baseclick GmbH, Munich, Germany
  • Microsoft Research, Cambridge United Kingdom (Associate partner).


ClickGene:
The Horizon 2020 Innovative Training Network (ITN) ClickGene is a research project in the field of click chemistry and gene therapy. The modification, activation, modulation and repression of DNA functional domains bring an overwhelming potential for human health applications.


Project participants:
  • Ludwig Maximilian University, Germany
  • National Center for Scientific Research "Demokritos", Greece
  • National Research Council, Italy
  • Institute of Organic Chemistry and Biochemistry ASCR, Czech Republic
  • University of Oxford, United Kingdom

and the companies:

  • ATDbio Ltd. , United Kingdom
  • baseclick GmbH, Munich, Germany
  • LipiNutraGen srl., Italy